Malignant extragonadal yolk sac tumor of the cervix in a 2-year-old female: case report

  • Aeia R Agarano Davao Medical School Foundation
  • Andrew U Alvarez Davao Medical School Foundation
  • Chastitee M Amora Davao Medical School Foundation
  • Alvin P Arreola Davao Medical School Foundation
  • Catherine E Autida Davao Medical School Foundation
  • Tessa Marie R Balboa Davao Medical School Foundation
  • Glennilyn L Bantilan Davao Medical School Foundation
  • Rocelyn M Barrientos Central Philippine University
  • Benjamin Alejandro R Untalan Davao Medical School Foundation
  • Cheryl Lyn A Diez Southern Philippines Medical Center
  • Maria Theresa Sanchez Southern Philippines Medical Center
  • Mae Concepcion Dolendo Southern Philippines Medical Center

Abstract

Extragonadal germ cell tumors (EGGCT) are rare neoplasms. Yolk sac tumors (YST), a histologic variant of EGGCT, is rarely found in the cervix, especially among infants. We report a 2-year-old girl who presented with a 6-week history of foul smelling vaginal discharge and a cervical mass on computed tomography. Diagnosis of YST was established through biopsy, positive immunohistostaining with SALL4, placental alkaline phosphatase (PLAP) and alpha-fetoprotein (AFP), and an elevated serum AFP level. Because surgery can possibly affect the patient’s reproductive capacity adversely, we initially decided to aim for remission with chemotherapy. The presence of a residual mass post-chemotherapy and an increasing trend in serum AFP levels prompted us to do radiotherapy for local control of the mass with incomplete tumor response.

Published
Oct 19, 2016
Issue
Vol 2 No 1 (2016)
Section
Case report

Keywords

cervico-uterine mass; germ cell tumor; radiotherapy; chemotherapy; immunohistostaining
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