Synchronous adenocarcinoma of colon and urothelial carcinoma: case report
Abstract
Synchronous renal and colon malignancies is a recognized clinical entity with low incidence. The relationship between these two cancers remains unclear, but various genetic and environmental factors have been implicated in the pathogenesis. A 52-year-old Filipino female with a palpable supraumbilical mass underwent a series of examinations, which revealed a transverse colon mass, and an incidental finding of a right renal mass. We did an extended right hemicolectomy and right radical nephrectomy, with an uneventful postoperative course. Histopathologic examinations revealed colonic adenocarcinoma and urothelial cell carcinoma of the right renal pelvis. Future plans for the patient include providing adjuvant chemotherapy using the Mayo regimen and performing ureterectomy with bladder cuff. The diagnosis of two distinct primaries was only established through postoperative histopathology results, which resulted in a delayed definitive management of the urothelial cell carcinoma. A frozen section biopsy, which is not routinely done for the surgical management of renal masses, would have contributed to an accurate intraoperative diagnosis and a more immediate and appropriate management of the urologic malignancy.
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