Biopsychosocial factors affecting the treatment outcomes of pulmonary tuberculosis among patients enrolled in TB DOTS clinics
Abstract
Background. An exploration of the influence of biopsychosocial factors on the treatment outcomes of patients with pulmonary tuberculosis (PTB) can prove helpful in the holistic management of patients with the disease.
Objective. To determine the biopsychosocial factors that affect the treatment outcomes of PTB patients enrolled in tuberculosis directly observed therapy short course (TB DOTS) clinics.
Design. Cohort study.
Setting. Two TB DOTS clinics in Tagum City, Philippines, between August 2013 and July 2014.
Participants. 127 male and female patients who were newly enrolled in the TB DOTS clinics for PTB.
Main outcome measures. Odds ratios (95% CI) of treatment failure for selected biopsychosocial factors.
Main results. There were 93 (73.23%) males and 34 (26.77%) females in the study, with an overall mean age of 44 ± 17 years. PTB treatment failed in 38 (29.92%) of the patients. The multivariate odds ratios of treatment failure were 0.24 (95% CI 0.09 to 0.60, p=0.0023) for a family history of tuberculosis, 4.87 (95% CI 1.99 to 11.95, p=0.0005) for patients with more than one symptom of PTB, and 3.51 (95% CI 1.44 to 8.53, p=0.0056) for patients who come from a dysfunctional family. The treatment success group and treatment failure group were comparable in terms of age, sex distribution, educational attainment, employment status, and household size.
Conclusion. A family history of tuberculosis significantly decreased, while having more than one PTB symptom and coming from a dysfunctional family significantly increased the odds ratios of PTB treatment failure.
Keywords
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